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本文用细胞培养方法，观察脑血管内皮细胞粘附分子（ＩＣＡＭ－１）的表达和内皮细胞与血液单核细胞的粘附作用。结果显示，１０ｕ／ｍｌＴＮＦ－α即可使内皮细胞ＩＣＡＭ－１表达增加，自发性高血压大鼠（ＳＨＲ）增加的程度大于正常血压大鼠（ＷＫＹ）。干扰素（ＩＦＮ）和白细胞介素１（ＩＬ－１）也可使ＩＣＡＭ－１表达增加。高浓度细胞因子均使ＳＨＲ和ＷＫＹ内皮细胞ＩＣＡＭ－１表达增加，但二者之间无明显差别。经ＬＰＳ或ＩＬ－１和ＴＮＦ－α刺激的ＳＨＲ内皮细胞与单核细胞的粘附率明显高于ＷＫＹ。结果证实，ＴＮＦ－α，ＩＬ－１和ＩＦＮ可使ＳＨＲ和ＷＫＹ脑血管内皮细胞ＩＣＡＭ－１表达和单核细胞粘附增加，两组动物细胞相比，ＳＨＲ内皮细胞ＩＣＡＭ－１表达及粘附率增加较多，提示ＳＨＲ脑血管内皮细胞可能对细胞因子的敏感性升高。
In this paper, the cell culture method was used to observe the expression of ICAM-1 and the adhesion of endothelial cells to blood mononuclear cells. The results showed that 10u / ml TNF-αcan increase the expression of ICAM-1 in endothelial cells, and the degree of spontaneous hypertensive rats (SHR) increased more than normal blood pressure rats (WKY). Interferon (IFN) and interleukin 1 (IL-1) also increase ICAM-1 expression. Both high concentrations of cytokines increased the expression of ICAM-1 in SHR and WKY endothelial cells, but there was no significant difference between the two. The adhesion rate of SHR endothelial cells to monocytes stimulated by LPS or IL-1 and TNF-α was significantly higher than that of WKY. The results confirmed that TNF-α, IL-1 and IFN could increase ICAM-1 expression and monocyte adhesion in SHR and WKY cerebrovascular endothelial cells. Compared with ICAM-1 expression and adhesion in SHR endothelial cells Rate increased more, suggesting that SHR cerebrovascular endothelial cells may be sensitive to cytokines.