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I_f电流是一种普遍存在于心肌自律细胞中特殊的心脏起搏电流,I_f通道开放后允许Na~+内流和K~+外流,最终形成一个缓慢而持续的内向电流,在心肌自律细胞自动除极化中起重要作用。I_f电流抑制后不仅能够降低静息心率且能有效地降低交感神经兴奋引起的心动过速,是理想的药物靶点。在对一系列的化合物筛选后,S16257~[1]因其降低心
I_f current is a special cardiac pacing current which is common in cardiac autonomic cells. I_f channel is open to allow Na ~ + influx and K ~ + outflow, which eventually leads to a slow and continuous inward current. Depolarization plays an important role. I_f current suppression can not only reduce the resting heart rate and can effectively reduce the tachycardia caused by sympathetic nerve activity is the ideal drug target. After screening a series of compounds, S16257 ~ [1] because of its lower heart