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腹腔注射吗啡(7.5mg/kg)或电针“夹脊”穴(3V,3Hz)均可使痛阈明显升高,脊髓内P物质样免疫活性物质(Ir-SP)含量及脊髓背角P物质样免疫反应物(SP-LI)显著增多(P<0.05～0.01)。腹腔注射吗啡加电针刺激,上述效应更为显著(P<0.01)。纳洛酮可阻断吗啡及电针所引起的痛阈升高和脊髓内Ir-SP含量增多的效应。结果提示:吗啡与电针的镇痛效应可能与经阿片受体为介导的脊髓内P物质增多有关。吗啡和电针对此具有协同作用。
Intra-abdominal injection of morphine (7.5mg / kg) or electro-acupuncture at “Jiaji” (3V, 3Hz) could significantly increase the pain threshold. The level of substance P-like immunoreactive substance Substance-like immunoreactive substance (SP-LI) increased significantly (P <0.05 ~ 0.01). Intraperitoneal injection of morphine plus electroacupuncture, the effect was more significant (P <0.01). Naloxone blocked morphine and electroacupuncture induced by increased pain threshold and increased intra-spinal Ir-SP effect. The results suggest that the analgesic effect of morphine and electroacupuncture may be related to the increase of substance P in the spinal cord mediated by opioid receptors. Morphine and electro-acupuncture have a synergistic effect on this.