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目的比较丝裂霉素C(MMC)与羟基喜树碱(HCPT)膀胱灌注对膀胱癌复发的预防作用及治疗毒性。方法筛选13个临床研究,包括416例进行MMC、595例进行HCPT膀胱灌注治疗的患者,进行系统分析。采用优势比(OR)及95%可信区间(95%CI)作为评价疗效及毒性差异的指标。统计软件为RevMan5。结果Meta分析显示,HCPT膀胱灌注治疗预防肿瘤复发的疗效显著优于MMC(P<0.01)。MMC组膀胱刺激症状、外周血白细胞数下降的发生率显著高于HCPT组(分别为P<0.01)。结论HCPT膀胱灌注预防膀胱癌复发作用优于MMC,且治疗毒性低于MMC。
Objective To compare the preventive and therapeutic effects of intravesical instillation of mitomycin C (MMC) and hydroxycamptothecin (HCPT) on the recurrence of bladder cancer. Methods Thirteen clinical studies, including 416 patients undergoing MMC and 595 patients undergoing HCPT bladder irrigation, were screened for systematic analysis. Odds ratio (OR) and 95% confidence interval (95% CI) were used as indicators to evaluate the efficacy and toxicity differences. Statistics software for RevMan5. Results Meta analysis showed that the curative effect of HCPT bladder irrigation on preventing tumor recurrence was significantly better than MMC (P <0.01). The incidence of bladder irritation and peripheral leukocyte count in MMC group was significantly higher than that in HCPT group (P <0.01, respectively). Conclusions HCPT bladder irrigation is superior to MMC in preventing the recurrence of bladder cancer and the therapeutic toxicity is lower than that of MMC.