论文部分内容阅读
目的探讨2型糖尿病(T2DM)患者甲状腺功能、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)检测的临床意义。方法 210例住院T2DM患者分成甲状腺功能正常组(A组,186例)、甲亢组(B组,8例)和甲减组(C组,16例),检测三组患者游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)及TGAb、TPOAb的水平。结果与A组比较,B组TSH明显减低(P<0.01);C组FT4明显减低(P<0.01),TSH明显增高(P<0.01)。B组及C组TPOAb阳性率分别为25%和50%,均明显高于A组的8.6%(P<0.01)。结论临床上可将TSH和TPOAb作为T2DM患者甲状腺功能的初筛指标。
Objective To investigate the clinical significance of thyroid function, thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in patients with type 2 diabetes mellitus (T2DM). Methods Totally 210 T2DM patients were divided into three groups: normal thyroid function group (A group, 186 cases), hyperthyroidism group (B group, 8 cases) and hypothyroidism group (C group, 16 cases) Acid (FT3), free thyroxine (FT4), thyrotropin (TSH) and TGAb, TPOAb levels. Results Compared with group A, the TSH in group B was significantly decreased (P <0.01). FT4 in group C was significantly lower (P <0.01) and TSH was significantly higher (P <0.01). The positive rates of TPOAb in group B and group C were 25% and 50%, respectively, which were significantly higher than those in group A (8.6%, P <0.01). Conclusion TSH and TPOAb can be clinically used as a screening index for thyroid function in patients with T2DM.