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目的:通过小鼠高架十字迷宫药效学实验对抗焦虑复方中药制剂中当归和川芎的两种制备工艺(煎煮法和双提法)进行优选。方法:健康雄性昆明种小鼠,随机分为空白对照组、阳性药地西泮组、抗焦虑中药(归芎煎煮法)高、中、低剂量组、抗焦虑中药(归芎双提法)高、中、低剂量组。空白对照组给予生理盐水及其余各组给药10d,第10d进行高架十字迷宫药效学测试,对开臂时间百分率和开臂次数百分率进行统计。结果:与空白对照组比较,地西泮组和归芎双提法高、中剂量组的开臂时间百分率和开臂次数百分率均有显著性差异(P<0.05),而归芎煎煮法各剂量组未见统计学意义。结论:采用双提法提取当归和川芎制备的抗焦虑中药的抗焦虑药效优于采用煎煮法的制剂。
OBJECTIVE: To optimize the two preparation techniques of Angelicae Sinensis and Chuanxiong Rhizome (anxiety and anti-Chuanxiong) by the method of elevated elevated plus maze in mice. Methods: Healthy male Kunming mice were randomly divided into blank control group, positive drug diazepam group, anti-anxiety Chinese medicine (high and medium low dose group), anti-anxiety Chinese medicine ) High, medium and low dose group. The blank control group was given normal saline and the other groups were administered for 10 days. On the 10th day, the patients were treated with elevated plus-maze pharmacodynamics test. The percentage of open arms and the percentage of open arms were counted. Results: Compared with the blank control group, both the percentage of open arms and the percentage of open arms in the high and middle dose groups of the two groups were significantly different (P <0.05) Each dose group did not reach statistical significance. Conclusion: The anti-anxiety efficacy of anti-anxiety Chinese medicine extracted by Angelica Sinensis and Chuanxiong by double extraction is better than that by decoction.