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磺胺甲氧吡嗪(简称 SMPZ)内服后,血中半衰期长达65小时。因其与血浆蛋白结合率较其他磺胺为低,故具有高游离值。血中浓度平均40%。每周服药2克,即可保持血中有效抗菌浓度(最低有效抑菌浓度为4.48微克/毫升)。我科曾采用三甲氧苄胺嘧啶与本品合用(TMP—SMPZ)对急性菌痢进行治疗,疗效满意。1974年秋季又单用 SMPZ 对20例急性菌痢进行试治,目的在于探讨单用 SMPZ 的疗效,
Sulfamethoxazole (abbreviation SMPZ) Oral, the blood half-life of up to 65 hours. Because of its binding rate with plasma protein than other sulfonamides, it has a high free value. Blood concentration average 40%. 2 grams per week, to maintain effective blood concentration of antibacterial (the minimum inhibitory concentration of 4.48 micrograms / ml). My department had used trimethoprim and this product (TMP-SMPZ) for the treatment of acute bacillary dysentery, the effect is satisfactory. In the autumn of 1974, 20 cases of acute bacillary dysentery were treated with SMPZ alone for the purpose of exploring the efficacy of SMPZ alone.