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目的：观察L-精氨酸抗动脉粥样硬化的作用是否与其抑制大鼠动脉血管细胞间粘附分子（intercellularadhesionmolecule，ICAM－1）的表达有关。方法：Wistar大鼠24只，随机分为NC组（普通饲料及饮水），CC组（饲料中含4％胆固醇，1％胆酸），AC组（饲料中含4％胆固醇，1％胆酸，饮水中含3％L-精氨酸盐酸盐）；每组8只。8周后采血，处死Wistar大鼠取其主动脉作ICAM－1的免疫组织化学及信使核糖核酸（mRNA）NorthernBlot分析。结果：AC及CC组大鼠的血清胆固醇浓度无显著差异，但明显高于NC组。NC及CC组大鼠血清L-精氨酸浓度无明显差异，但明显低于AC组（P＜0．01）。L-精氨酸抑制高胆固醇膳食诱发的大鼠动脉ICAM－1表达。结论：L-精氨酸抑制动脉ICAM－1表达作用可能是其抑制高胆固醇膳食诱发的动脉粥样硬化的分子机制之一。
Objective: To investigate whether the anti-atherosclerotic effect of L-arginine is related to the inhibition of intercellular adhesion molecule-1 (ICAM-1) expression in rats. Methods: Twenty-four Wistar rats were randomly divided into NC group (normal feed and drinking water), CC group (feed containing 4% cholesterol and 1% cholic acid), AC group (feed containing 4% cholesterol and 1% , 3% L-arginine hydrochloride in drinking water); 8 per group. After 8 weeks, the blood was collected and the Wistar rats were sacrificed and their aorta was taken for immunohistochemistry and messenger RNA (NorthernBlot) analysis of ICAM-1. Results: There was no significant difference in serum cholesterol between AC and CC groups, but significantly higher than NC group. There was no significant difference in serum L-arginine concentration between NC and CC groups, but it was significantly lower than that of AC group (P <0.01). L-Arginine Inhibits High Cholesterol Diet Induced ICAM-1 Expression in Rat Arteries. CONCLUSION: The inhibitory effect of L-arginine on the ICAM-1 expression in arteries may be one of the molecular mechanisms that inhibits the atherosclerosis induced by high cholesterol diet.