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应用免疫组化Ｓ—Ｐ法检测了６３例胃癌组织中抑癌基因Ｐ５３蛋白表达及其同传统的临床病理因素及雌孕激素受体表达的关系。结果，胃癌中Ｐ５３蛋白阳性率为３６．５％（２３／６３），其中呈阳性（）及强阳性（）者为１９．１％（１２／６３）。在各组织学类型癌中，高分化腺癌（包括乳头状腺癌）阳性率最低，为２４％（６／２５），印戒细胞癌阳性率最高达７５％（６／８）。Ｐ５３蛋白表达与胃癌浸润深度及淋巴结转移状态呈正相关，Ｐ５３阳性癌更易于穿透胃壁或发生淋巴结转移，但Ｐ５３表达与病人性别、年龄、肿瘤部位、大小及肉眼类型等因素无关。Ｐ５３表达阳性者，雌激素受体（ＥＲ）及孕雌素受体（ＰＲ）阳性率较低，呈负相关趋，但无统计学意义。结果提示，Ｐ５３蛋白表达与胃癌的生物学行为及进展可能有关。
Immunohistochemical S-P method was used to detect the expression of tumor suppressor gene P53 protein in 63 cases of gastric cancer and its relationship with traditional clinicopathological factors and expression of estrogen and progesterone receptors. As a result, the positive rate of P53 protein in gastric cancer was 36.5% (23/63), of which positive () and strong positive () were 19.1% (12/63). In each histological type of cancer, the positive rate of well-differentiated adenocarcinoma (including papillary adenocarcinoma) was the lowest, 24% (6/25), and the positive rate of signet-ring cell carcinoma was up to 75% (6/8). P53 protein expression was positively correlated with invasive depth and lymph node metastasis of gastric cancer. P53-positive cancers were more likely to penetrate the stomach wall or lymph node metastasis, but P53 expression was not related to the patient’s sex, age, tumor location, size, and the type of the naked eye. In patients with positive P53 expression, the positive rates of estrogen receptor (ER) and progesterone receptor (PR) were lower, showing a negative correlation trend but not statistically significant. The results suggest that the expression of P53 protein may be related to the biological behavior and progression of gastric cancer.