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在英格兰东北部采用以人群为基础的病例——对照研究,探讨原发性胆汁性肝硬化(PBC)的各种可能诱因。 病人和方法:从人口总数约二百万地区的卫生登记部门寻找病例。确诊PBC至少应具备下列标准中的2项:①线粒体抗体阳性滴度>1/40;②肝功能异常(包括胆红素、门冬氨酸转氨酶和碱性磷酸酶);③肝组织学检查确诊为PBC或与PBC相符。并应具备下述条件:①已确诊为PBC;②确诊日期1993年1月1日～1995年10月31日;③年龄≥18岁;④调查时正常居住在普查区域。从卫生部门的登记册中
A population-based case-control study was conducted in northeastern England to investigate various possible causes of primary biliary cirrhosis (PBC). Patients and Methods: To search for cases from the Health Registry at about 2 million in the population. The diagnosis of PBC should have at least two of the following criteria: ① mitochondrial antibody positive titer> 1/40; ② liver dysfunction (including bilirubin, aspartate aminotransferase and alkaline phosphatase); ③ liver histology Confirmed as PBC or consistent with the PBC. And should have the following conditions: ① has been diagnosed with PBC; ② diagnosis date January 1, 1993 ~ October 31, 1995; ③ age ≥ 18 years old; ④ survey normal residence in the census area. From the health department’s register