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目的:探讨津血源颗粒对干燥综合征(SS)模型鼠的治疗作用。方法:采用弗氏完全佐剂和百日咳、白喉、破伤风联合疫苗+同种鼠颌下腺抗原诱导,同时每天以0.6mg/kg利血平与50mg/kg甲状腺素灌胃,连续4周,建立类似临床SS动物模型。以津血源颗粒对SS模型鼠进行干预,观察津血源颗粒对SS模型鼠唾液分泌功能、体重、摄食量、饮水量、胸腺和颌下腺指数的影响。结果:津血源颗粒可以增加SS模型鼠的进食量、体重和唾液分泌量,缓解其口干症状,减少其饮水量,延缓SS模型鼠胸腺和颌下腺萎缩。结论:津血源颗粒可明显改善SS模型鼠的症状,对SS具有一定的治疗作用。
Objective: To investigate the therapeutic effect of Jinxueyuan Granules on Sjogren Syndrome (SS) model mice. METHODS: Freund’s complete adjuvant and pertussis, diphtheria, tetanus combined vaccine + submandibular gland antigen were induced. At the same time, 0.6mg/kg reserpine and 50mg/kg thyroxine were given every day for 4 weeks. Clinical SS animal model. The SS model mice were treated with Jinxuanyuan Granules to observe the effects of Jinxuanyuan Granules on salivary secretion function, body weight, food intake, water intake, and thymus and submandibular gland index in SS model rats. Results: Jinxuanyuan Granules could increase the food intake, body weight, and saliva secretion of SS model mice, alleviate their dry mouth symptoms, reduce their drinking capacity, and delay the atrophy of thymus and submandibular glands in SS model mice. Conclusion: Jinxueyuan Granule can obviously improve the symptoms of SS model mice and have a certain therapeutic effect on SS.