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[目的]①探讨颈动脉粥样硬化(CAS)与非酒精性脂肪肝(NAFLD)的关系,并研究两者的相关机制——血脂紊乱及炎症反应;②探讨相关指标与CAS伴NAFLD患者中医证型的关系,为其辨证论治提供参考。[方法]筛选CAS伴NAFLD患者74例作联合患病组,单纯CAS 25例作对照组,测定总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)等指标,在联合患病组进行指标间双变量相关分析;对比联合患病组各中医证型TC、TG、LDL-C、hs-CRP、TNF-α的差异并分析其辨证论治的参考指标。[结果]①联合患病组与对照组相比,TC[(5.75±0.77)、(4.71±0.97)mmol/L]、TG[(2.60±1.16)、(1.53±0.93)mmol/L]、hs-CRP[(3.21±1.32)、(1.85±1.07)mg/L]、TNF-α[(82.11±10.80)、(58.55±12.21)pg/ml]均P<0.01;而LDL-C[(3.33±0.86)、(2.88±0.96)mmol/L]P<0.05。②联合患病组TG与hs-CRP值呈显著的直线正相关(r=0.326,P<0.01)。③联合患病组中医证型构成比不同,TC、TG、LDL-C、hs-CRP、TNF-α在中医证型中分布规律不同,其中TC在痰瘀互结型、TG在脾虚痰湿型分别对比其他2型差异有统计学意义(P<0.01)。[结论]①CAS与NAFLD的关系密切,其两者的相关机制与血脂紊乱、炎症反应有关,可以认为NAFLD是AS的一个新的危险因素。②TC、TG分别可作为联合患病组痰瘀互结型、脾虚痰湿型辨证论治的参考。
[Objective] To investigate the relationship between carotid atherosclerosis (CAS) and nonalcoholic fatty liver disease (NAFLD), and to study the related mechanisms of the two - dyslipidemia and inflammatory reaction; (2) to explore the correlation between indicators and CAS with NAFLD in patients with Chinese medicine Syndromes of the relationship for its syndrome differentiation provides a reference. [Method] Totally 74 patients with CAS complicated with NAFLD were selected as the joint diseased group and 25 CAS alone as the control group. Total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) Hs-CRP, TNF-α and other indexes in the joint diseased group were analyzed by bivariate correlation analysis.Compared with TC, TG, LDL-C, C, hs-CRP, TNF-α differences and analysis of its reference index of syndrome differentiation. [Results] ① Compared with the control group, TC (5.75 ± 0.77), (4.71 ± 0.97) mmol / L and TG [(2.60 ± 1.16) and (1.53 ± 0.93) mmol / L, hs-CRP [(3.21 ± 1.32), (1.85 ± 1.07) mg / L] and TNF-α [(82.11 ± 10.80), (58.55 ± 12.21) pg / ml] 3.33 ± 0.86), (2.88 ± 0.96) mmol / L] P <0.05. ② There was a significant linear positive correlation between TG and hs-CRP in the combined illness group (r = 0.326, P <0.01). There was a significant difference in the distribution of TC, TG, LDL-C, hs-CRP and TNF-α between the TCM syndromes of TCM and TCM syndromes. Among them, Type respectively compared with other type 2 difference was statistically significant (P <0.01). [Conclusion] ① There is a close relationship between CAS and NAFLD. The related mechanisms are related to dyslipidemia and inflammatory reaction. NAFLD may be regarded as a new risk factor for AS. ②TTC and TG were respectively used as reference for syndrome differentiation of phlegm and blood stasis type and phlegm-dampness type of spleen deficiency syndrome in the joint diseased group.