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目的探讨孕晚期注射乙肝免疫球蛋白(HBIG)对乙型肝炎病毒(HBV)母婴传播阻断率的影响。方法对103例慢性HBV携带孕妇于孕晚期按1∶1比例随机分为注射HBIG组和对照组,两组新生儿出生2h内均尽快注射HBIG200IU,基因重组酵母乙肝疫苗每次10μg,按0、1、6月方案注射。新生儿于7月龄及12月龄时检测外周血HBV标记物。结果孕晚期注射HBIG组51例和对照组52例孕妇所生新生儿共103例,在7月龄、12月龄时均无HBV携带,阻断率均达100%。结论新生儿出生2h内尽快注射HBIG200IU,同时按0、1、6月方案规范注射乙肝疫苗,即可获得满意的HBV母婴传播阻断效果;孕晚期注射HBIG对提高HBV母婴传播阻断率无显著意义。
Objective To investigate the effect of hepatitis B immunoglobulin (HBIG) on the blocking rate of hepatitis B virus (HBV) transmission from mother to infant during the third trimester of pregnancy. Methods A total of 103 pregnant women with chronic HBV infection were randomly divided into two groups according to the ratio of 1: 1 in the third trimester of pregnancy. HBIG 200IU was injected within 2 hours after birth, 1, 6 months program injection. Perinatal HBV markers were tested at 7 and 12 months of age. Results In the third trimester of pregnancy, 51 newborns were injected with HBIG and 52 infants of the control group were pregnant with no HBV carriers at 7 and 12 months of age respectively. The blocking rates were all 100%. Conclusions HBIG200IU can be injected as soon as possible within 2 hours after birth, and satisfactory hepatitis B virus (HBV) and mother-to-child transmission can be obtained by injecting hepatitis B vaccine according to the protocol of 0, 1, and 6 months. In the third trimester of pregnancy, No significant meaning.