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目的对隐匿性乙型肝炎流行现状进行调查,分析HBV隐匿性感染血清学特点和高危感染因素。方法对1023例2007年1月-2013年1月深圳市人民医院乙肝表面抗原阴性的样本进行乙肝DNA定量检测;采用1:1配对的病例-对照展开隐匿性乙型肝炎感染的相关流行病学调查,通过多因素条件logistic回归分析探讨隐匿性乙型肝炎的感染高危因素。结果核酸检测结果显示:1023例HBsAg(-)样本中检测出65例HBV隐匿性感染病例,携带率为6.4%。血清学分析显示HBeAg(+)+HBcAb(+)的血清学模式感染隐匿性肝炎的风险较高。多因素条件logistic回归分析显示:年龄(OR=2.6)、职业(OR=1.7)、经济条件(OR=3.0)和合并感染(OR=6.8)是隐匿性乙型肝炎的感染高危因素。结论隐匿性乙型肝炎在人群中呈低流行趋势,HBcAb(+)+HBeAg(+)是隐匿性乙型肝炎感染的高危血清型;年龄、职业、经济条件、合并感染。是隐匿性乙型肝炎感染的高危因素。
Objective To investigate the prevalence of occult hepatitis B and analyze the serological features and risk factors of occult HBV infection. Methods A total of 1023 cases of hepatitis B surface antigen negative samples from Shenzhen People’s Hospital from January 2007 to January 2013 were tested for hepatitis B DNA. The cases of 1: 1 paired control-related epidemiology of occult hepatitis B To investigate the risk factors of occult hepatitis B infection by multivariate conditional logistic regression analysis. Results The results of nucleic acid test showed that 65 cases of occult HBV infection were detected in 1023 cases of HBsAg (-) samples and the carrying rate was 6.4%. Serological analysis showed that the serological pattern of HBeAg (+) + HBcAb (+) is at a higher risk of occult hepatitis. Multivariate logistic regression analysis showed that age (OR = 2.6), occupational (OR = 1.7), economic conditions (OR = 3.0) and combined infection (OR = 6.8) were risk factors for occult hepatitis B infection. Conclusions Occult hepatitis B shows a low prevalence in the population. HBcAb (+) + HBeAg (+) is a high-risk serotype of occult hepatitis B infection; age, occupation, economic conditions and co-infection. Is a high risk factor for occult hepatitis B infection.