论文部分内容阅读
咪芬替丁(Mifentidn,MT)是一个新的组胺H_2受体拮抗剂,其抗胃酸分泌作用比西咪替丁和雷尼替丁作用更强和作用时间更长。本文通过9例十二指肠溃疡病人随机双盲分组,每例一次口服MT10或20mg或安慰剂。测定药后30分钟基础胃酸、容积,pH和酸量,随后用蛋白胨刺激,测定2小时酸量、血浆胃泌素浓度和MT浓度。结果显示,基础胃酸被抑制,低剂量时为-78％和高剂量时为-98％,P<0.01,以蛋白胨刺激的胃酸量减少同药量有依赖关系,10mg
Mifentidn (MT), a new histamine H 2 receptor antagonist, has more potent anti-gastric acid secretion effects and longer duration of action than cimetidine and ranitidine. In this paper, 9 cases of duodenal ulcer patients were randomized to double-blind group, each time oral administration of MT10 or 20mg or placebo. The basal gastric acid, volume, pH, and acid amount were measured 30 minutes after the drug administration, followed by stimulation with peptone, and the acid amount, the plasma gastrin concentration and the MT concentration for 2 hours were measured. The results showed that the basal gastric acid was inhibited, -78% at low doses and -98% at high doses, P <0.01. The decrease of gastric acid with peptone was dependent on dose, and 10 mg