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克罗米芬(CC)用于促排卵已有30余年的历史,至今仍是最常用的治疗不孕症的药物,其诱导排卵成功率可达90％,但妊娠率远低于预期结果,原因在于CC的负面效应,一方面是对卵泡或对颗粒细胞的不良作用,另一方面在于对子宫内膜容受性和宫颈粘液的抗雌激素效应。有些研究表明,应用CC的患者子宫内膜成熟延迟,宫颈粘液质量差及子宫血流特性改变。因为CC半衰期长达5d,所以CC用药时间晚,其负面效应可能会延
Clomiphene citrate (CC) has been used for ovulation for more than 30 years and is still the most commonly used treatment for infertility. The success rate of inducing ovulation is up to 90%, but the pregnancy rate is much lower than the expected result The negative effects of CC are on the one hand the adverse effects on the follicles or on granulosa cells and on the other hand the anti-estrogenic effects on endometrial receptivity and cervical mucus. Some studies have shown delayed endometrial maturation in patients with CC, poor quality of cervical mucus, and altered uterine flow characteristics. Because CC half-life of up to 5d, so CC medication late, the negative effects may be delayed