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在遗传上有缺陷的动物,具有能够近似地模拟人类某些疾病的特性。从而为这类疾病的发生机制、病因和防治等研究提供理想的模型。目前,仅免疫缺陷型动物就有20多种。其中T—细胞缺陷型裸小鼠是国内外最为常用的动物模型,已为肿瘤学、免疫学和遗传学等研究作出重要贡献。裸鼠的育成早在1850年,Gordon就发现了野生无毛小鼠,后Gaskoin(1856)也有同样的发现,并观察到无鼠间交配的后代亦为无毛。1907年Campbell证明无毛性
Genetically defective animals have characteristics that can simulate certain diseases in humans. Thus providing an ideal model for the study of the pathogenesis, etiology and prevention of such diseases. Currently, there are more than 20 immune-deficient animals alone. Among them, T-cell deficient nude mice are the most commonly used animal models both at home and abroad, and have made important contributions to oncology, immunology and genetics. Nude mice were bred as early as 1850, and Gordon discovered wild hairless mice. Gaskoin (1856) later found the same finding and observed that hairlessness was also observed in offspring that did not cross between mice. Campbell proved glabrous in 1907