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目的探讨克罗米芬+己酮可可碱治疗特发性少、弱精子症的临床效果。方法选取门诊少、弱精子症患者300例,随机分为两组,A组(n=156)口服克罗米芬(50mg,q.d)+己酮可可碱缓释片(400mg,b.i.d)+VitE(100mg,t.i.d);B组(n=144)只服用VitE(100mg,t.i.d),共3个月,比较两组间各自用药前后的精液参数。进一步将A组患者分成少精子症(n=69)和弱精子症(n=87)2组,比较两者联合药物治疗前后精液各参数。结果(1)联合药物治疗3个月后,A组的精子活率、a级活动精子率、(a+b)级活动精子率等参数明显增加(P<0.05),但精液量、精子密度和活动精子总数无明显差异(P>0.05);B组精液各参数没有明显变化。(2)少精子症组联合药物治疗后精子密度、精子活率、活动精子总数明显提高(P<0.05);而弱精子症组仅精子活率明显提高(P<0.05),精子密度和活动精子总数没有明显变化(P>0.05)。结论克罗米芬+已酮可可碱能显著提高特发性少精子症患者的精子密度、精子活率、活动精子总数,以及特发性弱精子症的精子活率。
Objective To investigate the clinical effect of clomiphene and pentoxifylline in the treatment of idiopathic and asthenospermia. Methods A total of 300 patients with asthenospermia were randomly divided into two groups. A group (n = 156) was given clomifene (50 mg, qd) and pentoxifylline sustained-release tablets (400 mg, bid) , tid). Group B (n = 144) received only VitE (100 mg, tid) for 3 months. The semen parameters before and after treatment were compared between the two groups. Group A patients were further divided into two groups: oligozoospermia (n = 69) and asthenospermia (n = 87). The parameters of semen before and after the combination of the two drugs were compared. Results (1) After 3 months of combination therapy, the parameters of sperm motility, a-activity sperm motility, (a + b) activity sperm motility were significantly increased in group A (P <0.05) There were no significant differences in sperm motility between the two groups (P> 0.05). (2) Sperm density, sperm motility and sperm motility were significantly increased in oligospermia group (P <0.05), but sperm motility was significantly higher in asthenospermia group (P <0.05). Sperm density and motility The total number of sperm did not change significantly (P> 0.05). Conclusions Clomiphene citrate and pentoxifylline can significantly increase sperm density, sperm motility, total sperm motility and sperm motility in idiopathic asthenospermia patients.