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为证实维生素D突击疗法对维生素D缺乏性佝倭病是否易造成中毒.方法 我们用Wistor大鼠建立幼鼠佝楼病模型并采用4个等级剂量的维生素 D_3(30万 IU,60万IU,90万IU,120万 IU)分别一次性肌注,并与正常对照组比较,观察幼鼠身长、体重、血钙,磷值,骨X片,骨病理及肾,大血管组织切片.结果 显示治疗各组的体格、生化、X光及病理学改变均恢复到正常对照组水平.佝偻病病变消失.经统计学处理,上述各实验组间均无显著性差异.肾、腹主动脉光镜下各组均未见病理性钙化斑.结论 上述4种大剂量均为治愈佝偻病安全,有效剂量.
To confirm vitamin D assault therapy on vitamin D-deficient Toyo disease is easy to cause poisoning.Methods We use Wistor rats to establish the model of young rat gall bladder disease and the use of four doses of vitamin D_3 (300000 IU, 600000 IU, 900 000 IU and 1.2 million IU) were intramuscularly injected respectively, and compared with the normal control group, the body length, body weight, blood calcium, phosphorus, bone X-ray, bone pathology and renal and large vascular tissue sections were observed. Physiological, biochemical, X-ray and pathological changes of all groups were recovered to the level of the normal control group, and the pathological changes of rickets were disappeared.After statistical analysis, there was no significant difference between the above experimental groups.Linea kidney, abdominal aorta under light microscope No pathological calcified plaques were observed in all groups.Conclusion The above 4 high doses are safe and effective dosages for curing rickets.