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人体中许多代谢酶活性的变化可直接反映各种环境因素对机体的影响。受燃煤烟雾中多环芳烃类物质的影响,宣威县产妇胎盘中芳烃羟化酶(AHH)和谷胱甘肽硫转移酶(GST)活性变化表现为:燃烟煤未改灶组产妇胎盘中AHH活性和AHH/GST比值升高,GST活性降低;其中AHH活性升高分别为无烟煤组和木柴组的3.36倍和3.08倍,达到0.037n mole/min/mg protein;AHH/GST比值分别为7.91和6.42倍,达到0.443;GST活性降低分别为1.93倍和1.96倍,其值为0.103μmole/min/mg Protein。此外还发现目前为所采因用的改炉改灶措施有利于降低烟煤未改灶组产妇胎盘中的AHH活性和AHH/GST比值及提高GST的活性,进而说明胎盘中AHH和GST活性的变化与室内空气燃煤污染密切相关。
Many changes in human metabolic enzyme activity can directly reflect the impact of various environmental factors on the body. Affected by polycyclic aromatic hydrocarbons (PAHs) in coal-fired smoke, the change of AHH and GST activity in maternal placenta of Xuanwei County was as follows: AHH activity and AHH / GST ratio increased, and GST activity decreased. AHH activity increased 3.36 times and 3.08 times, respectively, to 0.037 n mole / min / mg protein in anthracite group and firewood group; AHH / GST ratios were 7.91 and 6.42-fold to 0.443, respectively. The reduction in GST activity was 1.93 and 1.96 times, respectively, with a value of 0.103 μmole / min / mg Protein. In addition, it is also found that the measures taken by the converter to improve the stove are beneficial to reduce the AHH activity and AHH / GST ratio and increase the GST activity in the maternal placenta of bituminous coal without change, and then indicate the changes of the activity of AHH and GST in the placenta It is closely related to coal-fired indoor air pollution.