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目的评估抗反流治疗对哮喘并发反流性食管炎(GERD)的治疗效果。方法选择临床确诊的哮喘并发GERD的患儿36例,随机分成两组,A组单纯给予吸入的沙丁胺醇(喘乐宁)气雾剂100ug每天2次,布地奈德200ug每天2次,连续6周;B组除以上药物外加奥美拉唑10mg每天1次,吗丁啉5mg每天3次,连续6周。试验开始前和结束后分别对两组病人行肺功能检测。结果治疗后所有病人周发作频率明显减少或消失,症状缓解。肺活量(VC)、用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、用力呼气流量(PEF)、及以上实测值占预计值的百分比在B组较A组明显提高,两者有统计学差异,P<0.05。结论增加抗反流治疗明显改善患者临床症状和肺功能指标。
Objective To evaluate the therapeutic effect of anti-reflux therapy on asthma with reflux esophagitis (GERD). Methods Thirty-six children with clinically diagnosed GERD were randomly divided into two groups. Group A was given inhaled salbutamol aerosol 100ug twice daily and budesonide 200ug twice daily for 6 weeks ; Group B in addition to the above drugs plus omeprazole 10mg once daily, morphine 5mg 3 times a day for 6 weeks. Pulmonary function tests were performed on both groups before and after the start of the experiment. Results After treatment, the weekly frequency of all patients significantly reduced or disappeared, the symptoms were relieved. The vital capacity (VC), forced vital capacity (FVC), FEV1, forced expiratory flow (PEF), and the percentage of the above predicted values in the group B were significantly higher than those in the group A There is a statistical difference, P <0.05. Conclusion Increased anti-reflux therapy can significantly improve clinical symptoms and pulmonary function indicators.