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目的 观察甲基强的松龙在治疗重症哮喘中的作用。方法 6 9例重症哮喘患者随机分成两组 :治疗组 32人 ,除采用哮喘常规治疗方法外 ,再静脉注射甲基强的松龙 40mg ,每 4～ 6h 1次 ;对照组 37人采用常规治疗。观察疾病的恶化率 ,肺功能改善情况及平均住院日。结果 治疗组中有 2名患者病情恶化进行了气管插管呼吸机辅助呼吸 ,占 6 2 5 % (2 /32 ) ,而对照组 37人中有 9名需行辅助呼吸机通气占 2 4 3% (9/37) ,两组比较差异显著 (P <0 0 5 )。结论 重症哮喘早期运用甲基强的松龙能控制疾病的恶化 ,改善临床症状 ,缩短住院日期 ,节省医疗费用。
Objective To observe the role of methylprednisolone in the treatment of severe asthma. Methods Sixty-nine patients with severe asthma were randomly divided into two groups: 32 in the treatment group, and 40 mg of methylprednisolone intravenously once every 4 to 6 hours in addition to the conventional treatment of asthma. In the control group, 37 patients were treated with conventional therapy . To observe the deterioration rate of the disease, pulmonary function improvement and average length of stay. Results Two of the patients in the treatment group were exacerbated by the endotracheal intubation ventilator-assisted respiration, accounting for 62.5% (2/32) of the patients in the treatment group, while 9 of the 37 patients in the control group had ventilator assisted ventilation (2 4 3) % (9/37), the difference between the two groups was significant (P <0 05). Conclusion Severe asthma early use of methylprednisolone can control the deterioration of the disease, improve clinical symptoms, shorten the hospitalization date, save medical costs.