论文部分内容阅读
目的探讨凋亡抑制基因survivin在胃癌组织中的表达,及其与血管内皮生长因子(VEGF)的关系。方法采用免疫组织化学方法检测survivin、VEGF在22例正常胃粘膜组织和42例胃癌组织中的表达。结果survivin基因在正常胃粘膜组织中阳性表达率为13.64%,在42例胃癌组织中,阳性率为57.14%,与胃癌的淋巴结转移密切相关;VEGF在正常胃粘膜组织表达率为18.18%,在42例胃癌组织中,阳性率为69.05%,两者均与胃癌的淋巴结转移密切相关。结论survivin是血管的保护性基因,参与了肿瘤血管的形成。
Objective To investigate the expression of survivin gene in gastric carcinoma and its relationship with vascular endothelial growth factor (VEGF). Methods Immunohistochemistry was used to detect the expression of survivin and VEGF in 22 cases of normal gastric mucosa and 42 cases of gastric carcinoma. Results The positive rate of survivin gene was 13.64% in normal gastric mucosa tissues and 57.14% in 42 gastric cancer tissues, which was closely related to the lymph node metastasis of gastric carcinoma. The positive rate of VEGF in normal gastric mucosa was 18.18% In 42 cases of gastric cancer, the positive rate was 69.05%, both of which were closely related to lymph node metastasis of gastric cancer. Conclusion Survivin is a protective gene of blood vessels involved in the formation of tumor blood vessels.