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目的:对创伤性颅脑损伤患者血清、脑脊液中IL-18含量动态变化的临床意义及与预后的关系进行分析探究。方法:选取接受治疗的20例创伤性颅脑损伤患者作为实验组,选取10例健康人作为对照组,对两组的IL-18含量进行检测,观察两组的IL-18含量以及格拉斯哥预后分级(GOS)情况。结果:实验组患者伤后第10天的IL-18含量明显高于对照组,差别均有统计学意义(P<0.05)。实验组患者的格拉斯哥预后分级(4.5±1.5)与对照组的格拉斯哥预后分级(4.7±1.6)分没有明显差异,差别无统计学意义(P>0.05)。结论:创伤性颅脑损伤患者血清、脑脊液中IL-18含量动态变化的临床意义重大,明确患者体内的IL-18含量有利于患者预后的恢复。
Objective: To investigate the clinical significance of the dynamic change of IL-18 in serum and cerebrospinal fluid (CSF) of patients with traumatic brain injury and its relationship with prognosis. Methods: Twenty traumatic brain injury patients were selected as the experimental group and 10 healthy volunteers were selected as the control group. IL-18 levels in the two groups were measured. The levels of IL-18 and Glasgow prognostic grade (GOS) situation. Results: The content of IL-18 in the experimental group on the 10th day after injury was significantly higher than that in the control group (P <0.05). The Glasgow prognostic grade (4.5 ± 1.5) in the experimental group was not significantly different from the Glasgow prognostic grade (4.7 ± 1.6) in the control group, with no significant difference (P> 0.05). Conclusion: The clinical significance of the dynamic changes of IL-18 in serum and cerebrospinal fluid of traumatic brain injury patients is significant. It is clear that the IL-18 content in patients is beneficial to the recovery of prognosis.