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目的了解2000年至2008年临床胆汁普通培养分离细菌的种类,并分析主要分离菌株的耐药性。方法回顾性分析近9年710例胆囊炎和胆囊结石患者胆汁普通培养分离细菌的分布情况及耐药率;用微量稀释法进行药物敏感性测定。结果710例患者胆汁培养共分离出细菌435株,检出率为61.27%,前5位分别为大肠埃希菌、肠球菌、假单胞菌、肺炎克雷伯菌和凝固酶阴性葡萄球菌。革兰阴性杆菌对亚胺培南、阿米卡星的耐药率均低于10%,对常用青霉素类和头孢菌素类抗生素耐药率超过50%。结论胆汁分离细菌以肠道细菌为主,阿米卡星可以作为经验治疗的首选药物。
Objective To understand the types of bacteria isolated from clinical bile in 2000-2008 and to analyze the drug resistance of the main isolates. Methods A retrospective analysis of 710 cases of cholecystitis and gallbladder stones in nearly 9 years in bile culture of bacteria isolated from the distribution and rate of drug resistance; determination of drug sensitivity with micro-dilution method. Results Among the 710 patients, 435 bacteria were isolated from bile culture, the detection rate was 61.27%. The top five were Escherichia coli, Enterococcus, Pseudomonas, Klebsiella pneumoniae and Coagulase negative staphylococcus. Gram-negative bacilli to imipenem, amikacin resistance rates were less than 10%, commonly used penicillins and cephalosporins resistant rate of more than 50%. Conclusion Gut bacteria are mainly intestinal bacteria, and amikacin can be used as the first choice of experience treatment.