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目的通过检测食管鳞癌组织的P53蛋白表达情况,并分析P53基因与食管癌的相关性。方法收集2007年1月至2010年6月在我院进行治疗的食管癌患者66例,用免疫组织化学方法对患者癌组织的P53蛋白表达进行检测,并分析其表达阴性与阳性与患者生存率的关系。结果 P53基因阳性患者的5年生存率为25.0,阴性的生存率为47.1。结论食管鳞癌组织P53蛋白的表达可能对该类患者预后有影响。
Objective To detect the expression of P53 protein in esophageal squamous cell carcinoma and to analyze the correlation between P53 gene and esophageal cancer. Methods Sixty-six patients with esophageal cancer who were treated in our hospital from January 2007 to June 2010 were enrolled in this study. The expression of P53 protein in cancer tissues was detected by immunohistochemical method. The negative and positive expression rates of P53 protein in patients with cancer were analyzed. Relationship. Results The 5-year survival rate of patients with positive P53 gene was 25.0, and the negative survival rate was 47.1%. Conclusion The expression of P53 in esophageal squamous cell carcinoma may have an impact on the prognosis of these patients.