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立即型皮试反应是由抗原和与组织肥大细胞结合的IgE皮肤致敏抗体的互相作用产生,操作时必须使适量抗原溶液到达角层和表皮缓冲带以下,俾使与组织肥大细胞结合。IgE分子对肥大细胞和嗜碱性细胞有特殊亲和力。这一亲和力的固有特点有二:(1)IgE分子的Fc部具有附着于细胞的必要结构,(2)细胞浆膜表面的受体能结合IgE分子的Fc部。嗜碱性细胞和肥大细胞表面有大量免
The immediate dermal test results from the interaction of antigens with IgE skin-sensitizing antibodies that bind to tissue mast cells and must be handled in such a way that an appropriate amount of the antigen solution reaches below the cortex and epidermis buffer to bind to tissue mast cells. IgE molecules have special affinity for mast cells and basophils. There are two inherent characteristics of this affinity: (1) the Fc portion of an IgE molecule has the necessary structure for attachment to the cell, and (2) the receptor on the surface of the plasma membrane binds to the Fc portion of an IgE molecule. A large number of basophils and mast cell surface free