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目的:探讨头孢菌素致双硫仑样反应的发生机制、治疗及预防,引起临床医师的注意,避免其发生。方法:对18例使用头孢菌素饮酒后导致的双硫仑反应进行回顾性分析。结果:所有患者均给予对症处理,应用纳络酮、维生素C、补钾、补液治疗后,症状均于4小时内缓解。结论:在应用头孢菌素类药物不超过l周内饮酒或饮酒后即应用头孢菌素药物易致双硫仑样反应。
Objective: To investigate the mechanism, treatment and prevention of cephalosporin-induced disulfiram-like reaction and to attract the attention of clinicians to avoid its occurrence. Methods: A retrospective analysis of 18 cases of disulfiram reaction induced by cephalosporin drinking was conducted. Results: All patients were given symptomatic treatment, the application of naloxone, vitamin C, potassium, fluid treatment, the symptoms were relieved within 4 hours. CONCLUSIONS: Cephalosporin-like drugs are susceptible to the disulfiram-like response when cephalosporins are consumed within 24 hours of consuming alcohol or drinking alcohol.