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本文研究了丙种射线照后大鼠脾脏巨噬细胞的超微结构变化,特别着重于溶酶体的活动情况及其酸性磷酸酶(AcP)的活性。丙种射线照射导致脾脏巨噬细胞大规模地吞噬受损淋巴细胞和红细胞,于是在巨噬细胞内形成大量具有AcP酶活性并转化为异噬溶酶体(HPL)的异噬体。随后,部分大HPL出现绞窄,并分离形成许多小溶酶体。有部分大HPL进一步变扁平并伸出伪足样突起包围某些胞质区或细胞器(如小溶酶体)而形成自噬溶酶体。溶酶体的这些行为可能与巨噬细胞内溶酶体系统的调节或自我控制有关。
In this paper, the ultrastructural changes of rat splenic macrophages after irradiation with gamma rays were studied, with particular emphasis on the activity of lysosomes and the activity of acid phosphatase (AcP). Irradiation with gamma rays led to large-scale phagocytosis of damaged lymphocytes and erythrocytes by splenic macrophages, which formed large numbers of phagosomes with AcP enzyme activity and conversion to isolysomal lysosomes (HPL) in macrophages. Subsequently, some large HPL appeared strands, and separated to form many small lysosomes. Some large HPL further flattened and extended pseudopod-like protuberance surrounded by some cytoplasmic organelles (such as small lysosomes) and the formation of autophagy lysosomes. These actions of lysosomes may be related to the regulation or self-regulation of lysosomal systems in macrophages.