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目的 探讨慢性乙型肝炎(慢乙肝)患者体内一氧化氮(NO)和一氧化氮合酶(NOS)水平及其意义。方法 检测37例慢乙肝患者NO、NOS[诱生型NOS(iNOS)和结构型NOS(cNOS) ]、肝功能、乙型肝炎病毒(HBV)DNA和HBV基因型(GT)并做出统计分析。结果 慢乙肝患者组与正常对照组比较,NO和iNOS的浓度均明显升高(P <0 0 5 ) ;丙氨酸转氨酶(ALT)异常组与正常对照组及ALT正常组比较:NO和iNOS的浓度均明显升高(P <0 0 5 ) ;ALT正常组与正常对照组比较:NO的浓度明显升高(P <0 0 5 ) ;cNOS在各组间比较差异无统计学意义。在慢乙肝患者中:NO和iNOS浓度与ALT水平呈明显正相关(r=0 36 7,r=0 4 74 )。NO和NOS与HBVDNA指标间均无明显相关关系。不同基因型组之间,NO和NOS的浓度差异无统计学意义(P >0 0 5 )。结论 在慢乙肝患者中,存在NO和iNOS水平升高的现象。慢乙肝患者ALT升高时,NO浓度高,对机体损伤重;慢乙肝患者ALT正常者,NO对机体无明显的损伤。NO和NOS与HBVDNA是相对独立的检测指标。NO水平与不同HBVGT患者病情及预后不同无明显关系。
Objective To investigate the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in patients with chronic hepatitis B (chronic hepatitis B) and their significance. Methods NO and NOS [iNOS and cNOS], liver function, hepatitis B virus (HBV) DNA and HBV genotype (GT) of 37 chronic hepatitis B patients were detected and statistically analyzed . Results The concentrations of NO and iNOS in patients with chronic hepatitis B were significantly higher than those in normal controls (P <0.05). The levels of NO and iNOS in normal ALT group and ALT normal group were significantly higher than those in normal control group (P <0.05). Compared with normal control group, the concentration of NO in normal ALT group was significantly increased (P <0 05). There was no significant difference in cNOS between the groups. In patients with chronic hepatitis B, NO and iNOS concentrations were positively correlated with ALT levels (r = 0 367, r = 0 4 74). There was no significant correlation between NO and NOS and HBVDNA index. There was no significant difference in the concentrations of NO and NOS between different genotype groups (P> 0.05). Conclusion In patients with chronic hepatitis B, there is a phenomenon of elevated levels of NO and iNOS. Patients with chronic hepatitis B elevated ALT, NO concentration is high, heavy damage to the body; chronic hepatitis B patients with normal ALT, NO no significant damage to the body. NO and NOS and HBVDNA are relatively independent test indicators. NO levels and different HBVGT patients with different disease and prognosis no significant relationship.