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本文作者在经过了一系列体内、体外实验的基础上,进行了毒理学研究.在六个月的实验中,先后进行了实验动物的体重变化,血常规与尿常规.血清生化学指标、病理组织学及恢复期(二周)的观察指标;全部数据经统计学处理.动物:大鼠由长春白求恩医科大学实验动物部引进,为Wistar大鼠,体重180g～220g.狗为农家狗,由乡村收集,收购后统一进行处理,注射狂犬疫苗,服用驱虫剂,饲养一周后,开始测定正常指标,合格者可选用,体重7.5kg左右.样品“Rh_2”制剂,自制.批号920504.实验方法:大鼠随机分为高、中、低对照四组,每组动物30只;狗随机分为高、低、对照三组、雌雄各半,每组4只,称量体重.给药途径:口服.观察测定指标:①体重变化、结果为,在给药后1—8周内,各剂量组的大鼠体重增加较大,在12周后,增重减缓.P>0.
The authors carried out toxicological studies on the basis of a series of in vitro and in vivo experiments. In the six-month experiment, weight changes, blood routine and urine routine tests were performed successively. Serum biochemical indicators, pathology Observations of histology and recovery period (two weeks); all data were statistically processed. Animals: Rats were introduced by the Experimental Animal Department of Changchun Bethune Medical University and were Wistar rats weighing 180 g to 220 g. Dogs were farm dogs. Rural collection, after the acquisition of a unified treatment, injection of rabies vaccine, taking insect repellent, feeding for a week, began to determine the normal indicators, qualified candidates can choose, weighing about 7.5kg. Sample “Rh_2” preparation, homemade. Lot number 920504. Experimental method : The rats were randomly divided into high, medium, and low control groups, with 30 animals in each group. Dogs were randomly divided into three groups: high, low, and control groups, male and female, each of which was weighed. Routes of administration: Oral. Observation and determination indicators: 1 body weight changes, the result is that within 1 to 8 weeks after administration, the weight gain of rats in each dose group is larger, after 12 weeks, weight gain is slowed down. P>0.