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全球肿瘤发病率持续增高,我国已经成为肿瘤发病人数最多的国家,大多数肿瘤,特别是晚期恶性肿瘤患者,都将因癌性疼痛而服用阿片类药物止痛。长期使用阿片类药物如吗啡时,会导致药物耐受,从而影响吗啡类药物的止痛效果,最终降低和限制了阿片类药物在临床中的使用。关于吗啡药物耐受的神经生理学机制,目前认为是多方面的,而且并没有完全明了。在过去的几十年里,各国都进行了很多研
The global incidence of cancer continues to rise, China has become the country with the largest number of cancer incidence, most of the tumors, especially patients with advanced malignant tumors, will take opioid pain due to cancer pain. Long-term use of opiates, such as morphine, can lead to drug resistance, which in turn can affect the analgesic effect of morphine drugs, ultimately reducing and limiting opioid use in the clinic. The neurophysiological mechanisms for morphine drug resistance are currently considered to be multifaceted and not completely understood. In the past few decades, many countries conducted a lot of research