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许多研究显示促黄体激素释放激素长效类似物(LHRHa),如 Leuprolide acetate(LA)能有效地抑制中枢性性早熟(CCP)的临床及生化表现,并使生长速度与骨龄成熟速度减慢,预计最终身高亦得到改善。已知青春发育时生长激素(GH)分泌增加主要由脉冲振幅增加所致而与脉冲频率无关。为研究 LA 治疗时 GH 分泌的动态变化,选择4例女性及1例男性特发性 CCP 患儿,年龄4(7/(12) )～10(9/(12) )岁。试验前6个月内侧骨龄为7. 8～14岁。LA 皮下注射月剂量为27～40μg/kg。治疗2个月后重复 LHRH
Many studies have shown that LHRHa, such as Leuprolide acetate (LA), can effectively inhibit the clinical and biochemical performance of central precocious puberty (CCP) and slow down the growth rate and bone age maturation, The final height is also expected to improve. It is known that the increase of growth hormone (GH) secretion during adolescence is mainly caused by the increase of pulse amplitude regardless of the pulse frequency. In order to study the dynamic changes of GH secretion during the treatment of LA, 4 female and 1 male idiopathic CCP were selected, aged 4 (7 / (12)) ~ 10 (9 / (12)) years old. 8 months before the test, bone age was 7. 8 to 14 years old. LA subcutaneous injection monthly dose of 27 ~ 40μg / kg. LHRH was repeated 2 months after treatment