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低氧能诱导编码促红细胞生成素基因的转录 ,过程的具体分子机理一直不清。低氧诱导因子家族的克隆及其调控许多目的基因表达的发现 ,丰富了我们对机体氧感受的分子机理的认识。同时低氧诱导因子家族中各因子的表达差异 ,及其之间的相互调控 ,低氧诱导因子在低氧条件下的作用机理 ,对目的基因的调控及相互之间差异的阐明 ,对理解许多与组织缺氧有关的重要疾病如心血管疾病、中风、慢性阻塞性肺疾病 ,特别是肿瘤的病理生理过程有重要意义
Hypoxia can induce the transcription of the gene encoding erythropoietin, the specific molecular mechanism of which has been unclear. Hypoxia inducible factor family cloning and regulation of many gene expression of the discovery of the purpose of enriching our understanding of the molecular mechanisms of oxygen sensing. At the same time, the expression of various factors in hypoxia-inducible factor family and their mutual regulation, hypoxia-inducible factor in hypoxia mechanism, the regulation of the target gene and the differences between the elucidation of many Hypoxia and the organization of important diseases such as cardiovascular disease, stroke, chronic obstructive pulmonary disease, especially the pathophysiology of the tumor has important significance