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目的观察胃癌姑息手术后患者短时间内血清VEGF是否升高,从而推测外科手术应激是否促进残存瘤体的生长和转移。方法采用ELISA检测9例Ⅲb期胃癌姑息手术患者、13例Ⅲb期胃癌根治手术患者术前1天、术后1、3、7天的血清VEGF水平和14例Ⅲb期胃癌非手术患者在相同时间段的血清VEGF水平。结果3组患者之间血清VEGF水平有显著性差异,且各组前后自身对照也有显著性差异。结论Ⅲb期胃癌姑息手术患者的血清VEGF水平在短时间内有升高趋势。
Objective To observe whether serum VEGF levels increase in patients with gastric cancer after palliative surgery in a short time, so as to speculate whether surgical stress can promote the growth and metastasis of residual tumor. Methods Nine patients with stage Ⅲb gastric cancer were treated with palliative surgery by ELISA. One month before operation, 13 cases of stage Ⅲb gastric cancer radical operation, the serum VEGF level at 1, 3 and 7 days after operation and 14 cases of stage Ⅲb non-operation gastric cancer at the same time Segment serum VEGF levels. Results Serum VEGF levels were significantly different between the three groups, and there was also significant difference between before and after treatment in each group. Conclusion Serum VEGF levels in patients with stage Ⅲb gastric cancer palliative surgery increased in a short period of time.