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目的:观察固本安神汤治疗肺癌伴失眠的临床疗效。方法:将60例肺癌伴失眠心肾不交证患者随机分为对照组和治疗组各30例。对照组患者给予常规西药治疗,治疗组患者加用固本安神汤治疗,比较两组临床疗效。结果:治疗组总有效率为96.7%,对照组为93.3%,两组差异无统计学意义(P>0.05)。治疗后两组PSQI积分均较治疗前降低,差异均有统计学意义(P<0.05);两组治疗后PSQI评分比较,治疗组治疗3、4周PSQI积分均低于对照组(P<0.05)。治疗组治疗后中医主要证候积分均显著降低(P<0.05);对照组治疗后失眠多梦、心悸心烦、头晕耳鸣、咽干口燥证候积分降低(P<0.05);治疗后,治疗组心悸心烦、头晕耳鸣、咽干口燥、腰膝酸软证候积分均低于对照组(P<0.01)。治疗后KPS评分比较,治疗组改善率为73.3%,对照组为50.0%,治疗组明显优于对照组(P<0.05);治疗组不良反应发生率为13.3%(4/30),对照组不良反应发生率为46.7%(14/30),治疗组低于对照组(P<0.05)。结论:固本安神汤治疗肺癌伴失眠有较好临床疗效。
Objective: To observe the clinical efficacy of Guben Anshen decoction in treating lung cancer with insomnia. Methods: Sixty cases of lung cancer with insomnia and heart-kidney syndrome were randomly divided into control group and treatment group, 30 cases each. Patients in the control group were treated with conventional western medicine. Patients in the treatment group were treated with Gubengan Shen Tang, and the clinical efficacy was compared between the two groups. Results: The total effective rate was 96.7% in the treatment group and 93.3% in the control group, with no significant difference between the two groups (P> 0.05). The scores of PSQI in the two groups after treatment were lower than those before treatment (P <0.05). PSQI scores of the two groups after treatment were lower than those of the control group (P <0.05) ). After treatment, the scores of main syndromes of TCM in treatment group were significantly lower (P <0.05); after treatment, the control group had more insomnia, palpitations upset, dizziness, tinnitus and lower throat dryness scores (P <0.05) Group palpitations upset, dizziness, tinnitus, dry throat, waist and knees score were lower than the control group (P <0.01). The KPS score of the treatment group was 73.3% in the treatment group and 50.0% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The incidence of adverse reactions in the treatment group was 13.3% (4/30) The incidence of adverse reactions was 46.7% (14/30), the treatment group was lower than the control group (P <0.05). Conclusion: Gubengan Shen Tang treatment of lung cancer with insomnia has a good clinical effect.