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目的研究分析外周血的Th1辅助性细胞和Th2辅助性细胞与肺结核病变的严重性程度以及其临床疗效的关系。方法运用细胞内的细胞因子检测手段对60例肺结核病患者外周血的Th1与Th2的辅助性细胞亚群进行检验测试,根据病患在治疗之前的影像学肺部的病灶累积程度,以及在患者治疗前后的影像学变化进行分组式对比,此60例肺结核病患作为实验组,而32例健康者作为参照组。结果在治疗之前的实验组的Th1的辅助性细胞计数与Th2的辅助性细胞计数皆明显低于参照组(P<0.05),实验组Th1辅助性细胞计数值为(42.87±32.56),参照组为(109.85±48.52);实验组Th2辅助性细胞计数值为(13.54±11.67),参照组为(31.24±18.34)。结论经过推测,结核病的发生以及进展很可能与Th1的辅助性细胞低下有关系,而并非Th2辅助性细胞的免疫反应增强所导致,在经过成果的抗结合临床治疗之后,Th1的辅助性细胞也随之恢复。
Objective To study the relationship between the severity of pulmonary tuberculosis and the clinical efficacy of Th1-helper and Th2-helper cells in peripheral blood. Methods T cell subsets of Th1 and Th2 in peripheral blood of 60 patients with pulmonary tuberculosis were tested by intracellular cytokine detection. According to the degree of accumulation of lung lesions in patients before treatment and in patients Before and after treatment of imaging changes were grouped, the 60 cases of tuberculosis as experimental group, while 32 healthy subjects as a reference group. Results Th1 helper cell count and Th2 helper cell count in the experimental group before treatment were significantly lower than those in the reference group (P <0.05). Th1 helper cell count in the experimental group was (42.87 ± 32.56) (109.85 ± 48.52). The Th2 helper cell count in the experimental group was (13.54 ± 11.67) and that in the reference group was (31.24 ± 18.34). CONCLUSIONS It is postulated that the occurrence and progression of tuberculosis is likely to be related to a decrease in helper cells in Th1 rather than to an increase in immune responses in Th2 helper cells. After successful anti-binding clinical treatment, Th1 helper cells Followed by recovery.