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目的 :探讨外科切除非小细胞肺癌 (NSCLC)神经细胞黏附分子 (NCAM)表达的临床病理特征和预后意义及其与嗜铬素A(CgA)与突触素 (Syn)表达的相关性。 方法 :应用免疫组化LSAB法 ,观察NCAM、CgA、Syn在NSCLC中的表达 ,研究NCAM表达的临床病理相关性及与CgA、Syn表达的相关性 ,通过单因素和多因素方法分析NCAM对外科治愈性切除患者的预后价值。结果 :在 16 3例NSCLC中有 4 0例 (2 4 .5 4 % )表达NCAM ,在各种不同病理类型中 ,腺癌的表达率较高 (P <0 .0 5 )。NCAM的表达与CgA(P <0 .0 5 )、Syn(P <0 .0 0 5 )表达相关 ,也与肿瘤的T分期 (P <0 .0 0 5 )、N分期 (P <0 .0 5 )相关。单因素分析显示NCAM表达阳性组 5年生存率为 36 .80 % ,而阴性组为 5 0 .74 % (P >0 .0 5 ) ,多因素分析肿瘤分期 (P <0 .0 0 1)与患者性别 (P <0 .0 5 )是独立预后因素。结论 :表达NCAM的NSCLC患者生存期较短 ,但肿瘤分期与患者的性别是判别预后的独立因素 ,提示NCAM的表达仅仅是促进肿瘤进展众多生物学事件之一
OBJECTIVE: To investigate the clinicopathological characteristics and prognostic significance of the expression of neural cell adhesion molecule (NCAM) in surgically resected non-small cell lung cancer (NSCLC) and its relationship with the expression of Synuclein (CgA) and synaptophysin (Syn). Methods: The expression of NCAM, CgA and Syn in NSCLC was observed by immunohistochemical LSAB method. The clinicopathological correlation of NCAM expression and the expression of CgA and Syn were studied. The clinical data of NCAM were analyzed by single factor and multi-factor analysis. Prognostic value of curative resection. RESULTS: NCAM was expressed in 40 of 16 3 NSCLC cases (24.54%), with a higher expression of adenocarcinoma in all pathological types (P <0.05). The expression of NCAM was correlated with the expression of CgA (P <0.05) and Syn (P <0.05), but also with the T stage (P <0.05) and N stage (P <0. 0 5) related. Univariate analysis showed that the 5-year survival rate of NCAM positive group was 36.8%, while that of negative group was 50.74% (P 0. 05). The multi-factor analysis of tumor stage (P 0 01) And patient’s gender (P <0.05) were independent prognostic factors. CONCLUSION: The survival of NSCLC patients with NCAM is short, but the staging of cancer and the gender of patients are independent prognostic factors, suggesting that the expression of NCAM is only one of many biological events that promote tumor progression