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目的研究一氧化氮(NO)、血管内皮素-1(ET-1)和血管性血友病因子(vWF)水平与并发雷诺现象(RP)系统性红斑狼疮(SLE)的相关性,以探讨其在继发RP发病机制中的作用。方法以并发RP的SLE女性患者30例为研究对象,并用无RP的SLE女性患者30例作为阴性对照组,30名健康女性作为健康对照组,分别测定血清NO、vWF浓度及血浆ET-1浓度,并进行统计学分析。结果并发RP的SLE患者NO、ET-1及vWF浓度均明显高于无RP的SLE患者,后者又明显高于健康对照组,差异均有统计学意义(均P<0.01)。结论 NO、ET-1及vWF水平的升高可能加重血管病变并诱发RP的发生。
Objective To investigate the correlation between levels of nitric oxide (NO), endothelin-1 (ET-1) and von Willebrand factor (vWF) in patients with systemic lupus erythematosus (RLE) Its role in secondary pathogenesis of RP. Methods Thirty women with SLE complicated with RP were enrolled in this study. Thirty women with SLE without RP were selected as negative control group and 30 healthy women as healthy control group. Serum NO and vWF levels and plasma ET-1 concentration , And statistical analysis. Results The concentrations of NO, ET-1 and vWF in patients with SLE complicated by RP were significantly higher than those without SLE in patients with RP, and the latter were significantly higher than those in healthy controls (all P <0.01). Conclusions The increase of NO, ET-1 and vWF may aggravate the vascular pathology and induce the occurrence of RP.