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目的 探讨伴 11q2 3染色体异常急性白血病 (AL)的免疫表型特征。方法 采用流式细胞术和 12种系列相关性单克隆抗体对 14例伴 11q2 3染色体异常的初诊的非继发性急性白血病进行免疫表型研究。结果 14例 11q2 3异常急性白血病患者中 ,男 12例 ,女 2例 ;t(4 ;11) (q2 1;q2 3)急性淋巴细胞白血病 8例 ,免疫分型显示CD10 -CD19+、CD33+、CD34+仅各 1例 ;急性髓系白血病 5例 ,其中M5b、M3和M2a各 1例 ,4例CD34+,1例表达淋系抗原 (CD7+CD19+) ;浆细胞白血病 1例 ,所用的 12种单抗均阴性。结论 11q2 3异常ALL主要为B前体细胞 (CD10 -CD19+) ,11q2 3异常AML高表达CD34,提示此类患者起源于较早期的干 /祖细胞的恶性转化
Objective To investigate the immunophenotypic features of 11q2 3-negative acute leukemia (AL). Methods Flow cytometry and 12 series of monoclonal antibodies were used to screen 14 newly diagnosed non-acute leukemia patients with 11q2 3 chromosomal abnormality. Results There were 12 males and 2 females in 14 cases of 11q2 3 patients with acute leukemia. There were 8 cases of acute lymphoblastic leukemia in t (4; 11) (q2 1; q2 3). The immunophenotype showed CD10-CD19 +, CD33 +, CD34 + Only 1 in each case. There were 5 cases of acute myeloid leukemia, including 1 case of M5b, M3 and M2a, 4 cases of CD34 + and 1 case of lymphoid antigen (CD7 + CD19 +), 1 case of plasma cell leukemia, All negative. Conclusions The abnormalities of 11q2 3 ALL mainly are B precursor cells (CD10-CD19 +) and 11q2 3 abnormal AMLs highly express CD34, suggesting that these patients originate from the malignant transformation of earlier stem / progenitor cells