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目的分析甲状腺乳头状癌中TPO、HER-2的表达及临床意义。方法选择2011年1月至2014年5月49例甲状腺乳头状癌接受手术治疗的标本病例组织及其癌旁甲状腺良性病变组织。采用Envision二步法进行TPO和HER-2表达定位及半定量分析,并分析TPO、HER-2单检测以及两者联合检测在诊断甲状腺乳头状癌中的阳性率、敏感性、特异性和准确性。结果 TPO和HER-2在甲状腺乳头状癌患者和癌旁组织中的阳性表达率差异有统计学意义(P<0.05);TPO在甲状腺乳头状癌癌组织检测的阴性率为91.84%,癌旁组织中的检测阴性率为0.00%;HER-2在甲状腺乳头状癌癌旁组织中的阳性率为10.20%;在癌组织的阳性率为89.80%;TPO和HER-2具有不同的敏感性、特异性和准确性,但二者联合检测的敏感性、特异性和准确性较高。结论 TOP和HER-2在诊断甲状腺乳头状癌中具有不同的准确性、敏感性和特异性,二者联合检测其准确性、敏感性和特异性更高,联合应用对诊断更有价值。
Objective To analyze the expression of TPO and HER-2 in papillary thyroid carcinoma and its clinical significance. Methods From January 2011 to May 2014, 49 cases of thyroid papillary carcinoma underwent surgical treatment and benign thyroid lesions. The Envision two-step method was used to detect the localization and semi-quantitative expression of TPO and HER-2, and to analyze the positive rate, sensitivity, specificity and accuracy of TPO, HER-2 single detection and combined detection of TPO and HER-2 in the diagnosis of papillary thyroid carcinoma Sex. Results The positive rates of TPO and HER-2 in thyroid papillary carcinoma tissues and adjacent tissues were significantly different (P <0.05). The negative rates of TPO in thyroid papillary carcinoma tissues were 91.84% The positive rate of HER-2 in paracancerous tissues of papillary thyroid carcinoma was 10.20%; the positive rate in cancerous tissues was 89.80%; the sensitivity of TPO and HER-2 was different, Specificity and accuracy, but the combined detection of the two has higher sensitivity, specificity and accuracy. Conclusion TOP and HER-2 have different accuracy, sensitivity and specificity in the diagnosis of papillary thyroid carcinoma. The combined detection of TOP and HER-2 is more accurate, sensitive and specific, and the combined application is more valuable for diagnosis.