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以热板法镇痛效应为指标，测定了川芎挥发油表观药动学参数。给药剂量分别为ｉｐ５２ｍｇ／ｋｇ、９６ｍｇ／ｋｇ。药效动力学参数腹腔给药为：Ｋｅ＝０．１１３８ｈ１，Ｋａ＝３．３２６１ｈ１，ｔ１／２（ｋｅ）＝６．０９ｈ，ｔ１／２（ｋａ）＝０．２１ｈ，Ｔ（ｐｅａｋ）＝１．０５ｈ，Ｃ（ｍａｘ）＝５０．６２５５ｍｇ／ｋｇ，ＡＵＣ＝５２６．２３１５（ｍｇ／ｋｇ）·ｈ，ＣＬ／Ｆ（ｓ）＝０．１６３７ｍｇ／ｋｇ／ｈ／（ｍｇ／ｋｇ），Ｖ／Ｆ（ｃ）＝０．９１１４（ｍｇ／ｋｇ）／（ｍｇ／ｋｇ）；灌胃给药为：Ｋｅ＝０．０９２９ｈ１，Ｋａ＝０．７６９３ｈ１，ｔ１／２（ｋｅ）＝７．４６ｈ，ｔ１／２（ｋａ）＝０．９０ｈ，Ｔ（ｐｅａｋ）＝３．２４ｈ，Ｃ（ｍａｘ）＝４３３．９４４１ｍｇ／ｋｇ，ＡＵＣ＝３６１９．３８７７（ｍｇ／ｋｇ）·ｈ，ＣＬ／Ｆ（ｓ）＝０．０９５４ｍｇ／ｋｇ／ｈ／（ｍｇ／ｋｇ），Ｖ／Ｆ（ｃ）＝１．０２７４（ｍｇ／ｋｇ）／（ｍｇ／ｋｇ）。结果表明川芎挥发油ｉｐ及ｉｇ给药其体存量的表观药动学过程均符合一室开放模型，绝对生物利用度为６００２％。
With the analgesic effect of hot plate method as an indicator, the apparent pharmacokinetic parameters of volatile oil from Rhizoma Chuanxiong were determined. The doses were ip 52 mg/kg and 96 mg/kg, respectively. The pharmacodynamic parameters for intraperitoneal administration were: Ke=0.1138h-1, Ka=3.3261h-1, t1/2(ke)=6.09h, t1/2(ka)=0.21h, T ( Peak)=1.05 h, C(max)=50.6255 mg/kg, AUC=526.2315 (mg/kg)·h, CL/F(s)=0.1637 mg/kg/h/(mg/kg V/F(c) = 0.9114 (mg/kg)/(mg/kg); gavage administration: Ke = 0.0929h-1, Ka = 0.7693h-1, t1/2 ( Ke)=7.46 h, t1/2 (ka)=0.90 h, T(peak)=3.24 h, C(max)=433.9441 mg/kg, AUC=3619.3877 (mg/kg)·h ,CL/F(s)=0.0954mg/kg/h/(mg/kg), V/F(c) = 1.0274 (mg/kg)/(mg/kg). The results showed that the apparent pharmacokinetics of Chuanxiong volatile oil ip and ig administration were in line with the one-compartment open model, and the absolute bioavailability was 6002%.