论文部分内容阅读
文报告14例病人国产头孢哌酮的药代动力学与药效学研究结果。国产和进口头孢哌酮2g恒速静滴1h,血浓峰值分别为211μg/ml和252μg/ml。国产品V_n值为0.24L/kg,进口品为0.17L/kg(p<0.05),其余各项动力学参数无显著差异,药时曲线方程国产品为y=165.40e~(-2.3258t)+155.53e~(-0.2127t),进口品为y=145.93e~(-3.1223t)+230.99e~(-0.3199t)。国产品以双室模型模拟相关性为r=0.9669,败血症病人显效血浓为287±68μg/ml,呼吸道感染病人显放血浓为223±51μg/ml。产生毒副反应组与未产生毒副反应组血浓分别为295和178μg/ml(p<0.01)。
Paper reports 14 patients with domestic cefoperazone pharmacokinetics and pharmacodynamics research results. Domestic and imported cefoperazone 2g constant velocity intravenous infusion 1h, peak blood concentrations were 211μg / ml and 252μg / ml. The V_n value of domestic products was 0.24L / kg, and the imported products was 0.17L / kg (p <0.05). There was no significant difference in the other kinetic parameters. The domestic product of the drug curve equation was y = 165.40e -2.3258t, + 155.53e ~ (-0.2127t), imports = y = 145.93e ~ (-3.1223t) + 230.99e ~ (-0.3199t). The correlation between the two products was r = 0.9669 for domestic products, 287 ± 68 μg / ml for sepsis patients, and 223 ± 51 μg / ml for patients with respiratory tract infections. The blood concentrations of toxic and side effects groups were 295 and 178 μg / ml (p <0.01), respectively.