论文部分内容阅读
目的:对转移性大肠癌患者进行健脾解毒方联合化疗治疗的有效性和安全性进行对比与分析。方法:研究对象来源于医院收治的98例转移性大肠癌患者,根据随机数字表法随机分为观察组和对照组,每组49例患者。对照组患者给予常规化疗方法进行对症治疗,观察组患者应用在对照组基础上联合健脾解毒方法治疗。对比两组患者的生活质量评分、肢体功能评分、心理及精神状况评分情况、临床疗效评价及不良反应发生率。结果:观察组患者经治疗后的生活质量评分(92.52±7.22)分、肢体功能评分(94.04±3.22)分、心理及精神状况评分(95.59±1.49)分、治疗总有效率(89.80%)及不良反应发生率(16.33%)均明显优于对照组生活质量评分(71.92±8.07)分、肢体功能评分(78.23±4.21)分、心理及精神状况评分(81.14±1.67)分、治疗总有效率(59.18%)及不良反应发生率(48.98%),其差异具有统计学意义(P<0.05)。结论:应用健脾解毒方联合化疗对转移性大肠癌患者进行治疗,患者生活质量有明显提高,不良反应较小,安全性较高,其短期临床疗效显著,但远期的临床效果仍然需要通过延长随访时间和加大样本量来进行证实。
Objective: To compare and analyze the efficacy and safety of Jianpi Jiedu Decoction combined with chemotherapy in patients with metastatic colorectal cancer. Methods: A total of 98 patients with metastatic colorectal cancer who were admitted to our hospital were randomly divided into observation group and control group according to random number table method, with 49 patients in each group. Patients in the control group were treated with conventional chemotherapy for symptomatic treatment. Patients in the observation group were treated with combination of spleen and detoxification on the basis of the control group. Quality of life scores, limb function scores, mental and mental status scores, clinical efficacy evaluation and incidence of adverse reactions were compared between the two groups. Results: The quality of life score (92.52 ± 7.22), limb function score (94.04 ± 3.22), mental and mental status score (95.59 ± 1.49) and total effective rate (89.80%) in the observation group and The incidence of adverse reactions (16.33%) were significantly better than those in the control group (71.92 ± 8.07), limb function score (78.23 ± 4.21), mental and mental status score (81.14 ± 1.67), total effective rate (59.18%) and adverse reactions (48.98%), the difference was statistically significant (P <0.05). Conclusion: The treatment of patients with metastatic colorectal cancer treated with Jianpi Jiedu decoction combined with chemotherapy has significantly improved quality of life, less adverse reactions, higher safety and short-term clinical curative effect, but the long-term clinical effect still needs to be passed Extend the follow-up time and increase the sample size to confirm.