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目的:观察醒脑静与盐酸纳洛酮治疗处于昏迷状态的脑出血患者的临床效果。方法:临床纳入处于昏迷状态的脑出血患者90例,根据治疗方案的不同分为研究组与对照组。对照组在脑出血常规治疗的基础上加用盐酸纳洛酮,研究组则在脑出血常规治疗的基础上加用醒脑静与盐酸纳洛酮。观察两组患者治疗有效率、脑水肿量、格拉斯哥昏迷(GCS)评分、美国国立卫生院神经功能缺损评分(NIHSS)、昏迷持续时间以及不良反应情况等。结果:研究组治疗有效率为91.11%,高于对照组的71.11%,差异有显著性(P<0.05);治疗后研究组脑血肿量为(26.45±4.19)m L、GCS评分为(9.95±1.84)分,对照组脑血肿量为(18.63±3.39)m L、GCS评分为(14.27±1.78)分,差异均有显著性(P<0.05);研究组平均昏迷持续时间为(7.39±2.97)d,对照组平均昏迷持续时间为(13.29±3.63)d,差异有显著性(P<0.05);两组患者NIHSS评分在治疗前以及出院前差异均无显著性(P>0.05),出院后3个月研究组为(9.95±2.04)、对照组为(12.15±2.51),显著有显著性(P<0.05)。治疗期间,研究组不良反应发生率为4.44%,对照组不良反应发生率为13.33%,差异无显著性(P>0.05)。结论:醒脑静与盐酸纳洛酮治疗处于昏迷状态的脑出血患者的临床疗效确切,能够有效提高治疗的有效率,迅速减轻脑水肿,减少昏迷时间,改善神经功能,且不良反应发生率较低,值得推广。
Objective: To observe the clinical effect of xingnaojing and naloxone hydrochloride in patients with cerebral hemorrhage in coma. Methods: Ninety patients with cerebral hemorrhage who were in a coma were enrolled in the study. According to the treatment plan, they were divided into study group and control group. The control group was given naloxone hydrochloride on the basis of conventional treatment of cerebral hemorrhage. The study group added xingnaojing and naloxone hydrochloride to the routine treatment of cerebral hemorrhage. Efficacy of treatment, cerebral edema volume, Glasgow Coma Scale (GCS) score, NIHSS, coma duration and adverse reactions were observed in two groups. Results: The effective rate of the study group was 91.11%, higher than 71.11% of the control group, the difference was significant (P <0.05); after treatment, the cerebral hematoma volume was (26.45 ± 4.19) m L and the GCS score was (9.95 ± 1.84). The volume of cerebral hematoma in the control group was (18.63 ± 3.39) m L and the GCS score was (14.27 ± 1.78) min (P <0.05). The coma duration in the study group was (7.39 ± 2.97) d, and the mean duration of coma in the control group was (13.29 ± 3.63) d, with significant difference (P <0.05). There was no significant difference in NIHSS score between the two groups before treatment and before discharge (P> 0.05) At 3 months after discharge, the study group was (9.95 ± 2.04) and in the control group (12.15 ± 2.51), significantly (P <0.05). During the treatment, the incidence of adverse reactions was 4.44% in the study group and 13.33% in the control group, with no significant difference (P> 0.05). Conclusion: The effect of xingnaojing and naloxone hydrochloride in patients with cerebral hemorrhage in coma is effective, which can effectively improve the efficiency of treatment, reduce cerebral edema rapidly, reduce coma time, improve neurological function, and the incidence of adverse reactions Low, worth promoting.