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幼稚红细胞的巨型变化,首先发现于恶性贫血患者骨髓中,此后注意到:凡是干扰人体维生素B_(12)或叶酸代谢过程的药物均可致此种现象。从而这种细胞形态的变化,就成了提示和诊断此类疾患的重要依据。近年来,人们又注意到:类似的细胞形态变化对红白血病及白血病前期诊断亦具价值。我们体会,晚期幼红细胞(中幼红和晚幼红)的巨大畸形,并不仅见于上述疾病中。为了阐明巨型晚期幼红细胞在骨髓涂片中出现的情况,及其可能提示的临床意义,做了如下工作。 一、材料和方法 骨髓涂片472例,主要为治疗前的各种血液病,
The immature erythrocyte giant changes, first found in the bone marrow of patients with pernicious anemia, since then: all interfere with the body of vitamin B 12 (12) or folic acid metabolism of drugs can be caused by this phenomenon. Thus this change in cell morphology has become an important basis for the prompt and diagnosis of such disorders. In recent years, people also noticed: similar changes in cell morphology of erythroleukemia and leukemia also valuable early diagnosis. We realize that the great deformities of late erythroid cells (immature red and late crimson) are not only found in the above diseases. In order to elucidate the occurrence of giant late erythroid cells in bone marrow smear, and its possible clinical significance, the following work has been done. First, the material and methods Bone marrow smear 472 cases, mainly for the treatment of various blood diseases,