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目的 :探讨结直肠癌淋巴结转移规律及其影响的相关因素。方法 :91例完整切除的结直肠癌患者的手术标本 ,将逐一清除的淋巴结分别送检 ,同时采用免疫组化的方法检测 E- cad和 TIMP- 3在肿瘤组织中的表达情况 ,结合临床病理资料分析结直肠癌淋巴结转移与诸因素的关系。结果 :91例结直肠癌患者中 33例发生淋巴结转移 ,共清除淋巴结 974枚 ,其中 1 1 3枚发生转移。影响淋巴结转移的因素有 1年龄 :小于 4 0岁的结直肠癌患者的淋巴结转移高于其他两组 (P =0 .0 36 ) ;2肿瘤的侵袭程度 :随着侵袭程度的加深 ,淋巴结转移的机会越大 (P <0 .0 0 5 ) :3E- cad和 TIMP- 3在肿瘤组织中的表达与否淋巴结的转移呈副相关 ,且差异具有显著性 (P值均 <0 .0 5 )。结论 :结直肠癌淋巴结的转移与年龄、肿瘤侵袭的程度以及 E- cad和TIMP- 3在肿瘤组织中的表达情况有关 ,根据这些因素可以初步估计结直肠癌患者淋巴结转移情况 ,从而指导手术和术后辅助治疗 ,以及判断患者的预后
Objective: To investigate the regularity of lymph node metastasis and related factors in colorectal cancer. Methods: Totally 91 resected patients with colorectal cancer were examined with immunohistochemical methods to detect the expression of E-cadherin and TIMP-3 in the tumor tissue. Data analysis of colorectal cancer lymph node metastasis and the relationship between various factors. Results: Lymph node metastasis occurred in 33 of 91 patients with colorectal cancer. A total of 974 lymph nodes were removed, of which 113 were metastatic. There are 1 factors influencing lymph node metastasis: the lymph node metastasis of colorectal cancer patients younger than 40 years old is higher than that of the other two groups (P = 0.036); 2 The degree of tumor invasion: With the deepening of invasion, lymph node metastasis (P <0.05): The expression of 3E-cad and TIMP-3 in the tumor tissue was negatively correlated with lymph node metastasis, and the difference was significant (P <0.05) ). Conclusion: The lymph node metastasis of colorectal cancer is related to the age, the extent of tumor invasion and the expression of E-cadherin and TIMP-3 in the tumor tissue. Based on these factors, the lymph node metastasis in patients with colorectal cancer can be preliminarily estimated to guide the operation and Postoperative adjuvant therapy, and to determine the prognosis of patients