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本文观察了重组人肿瘤坏死因子α(rTNF-α)对白血病细胞株U937,Raji和新鲜急非淋白血病祖细胞(CFU—L)生长的作用。证实TNF—α能够显著抑制自血病细胞的增殖,但不同的白血病细胞对TNF—α敏感性有一定的差异。细胞毒效应可能是其主要的作用机制。
This study investigated the effect of recombinant human tumor necrosis factor alpha (rTNF-α) on the growth of leukemic cell lines U937, Raji and fresh acute non-leukemia progenitor cells (CFU-L). Confirmed that TNF-α can significantly inhibit the proliferation of leukemia cells, but different leukemia cells have a certain difference in the sensitivity of TNF-α. Cytotoxic effects may be its main mechanism of action.