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本文报告了口服氧氯化锑结晶对小白鼠的毒性和日本血吸虫病的实验治疗作用及预防作用。小白鼠口服氧氯化锑的10天亚急性LD_(50)为17.4毫克/20克鼠重,略小于同样条件下测得的酒石酸锑钾的LD_(50)(20.0毫克/20克鼠重)。用每天1.5毫克/23克鼠重的剂量,连续10天治疗病鼠,灭虫率达89.6%;用十天亚急性LD_(50)×0.85量(11.2毫克),给病鼠分14天口服治疗,灭虫率达95.1%,平行试验下的酒石酸锑钾的灭虫率为84.0%。故氧氯化锑结晶口服治疗小白鼠日本血吸虫病有效,且在等毒剂量下,优于酒石酸锑钾。用小白鼠感染日本血吸虫尾蚴后,不同阶段投药的方法,研究了氧氯化锑结晶,对日本血吸虫病的预防作用,似见随用药时间推迟而作用增强,虫子发育率下降,故本品对小白鼠日本血吸虫病有一定预防作用。本文最后提出了一些口服锑剂可能在消化道中离解为氧氯化锑发挥抑虫作用的推断。
This paper reports the oral administration of antimony oxychloride crystals on mice toxicity and experimental treatment of Schistosoma japonicum and its preventive effect. The 10-day subacute LD 50 of mice administered with antimony oxychloride was 17.4 mg / 20 g mouse weight, slightly less than that of the LD 50 (20.0 mg / 20 g mouse weight) of antimony potassium tartrate measured under the same conditions. . The mice were treated with 1.5 mg / 23 g mouse weight daily for 10 days and the rate of extermination was 89.6%. The mice were given oral administration of LD50 (50) × 0.85 (11.2 mg) for 10 days Treatment, the rate of pest control 95.1%, parallel test under the anti-insect rate of antimony potassium tartrate was 84.0%. Therefore, antimony oxychloride crystal oral administration of Japanese schistosomiasis effective, and at the same dose, better than antimony potassium tartrate. In mice infected with Schistosoma japonicum cercariae after spraying at different stages of the method to study the crystallization of antimony oxychloride, the prevention of schistosomiasis japonicum, it seems with the delay in the role of drugs and increased delay, so the rate of development of insects, so the goods on the Japanese schistosomiasis japonica has a preventive effect. This article concludes with some conclusions that some oral antimony agents may be dissociated into antimony oxychloride in the digestive tract to exert their inhibitory effect.