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目的 探讨食管、贲门癌组织中抑癌基因P16表达与肿瘤的某些病理特点,临床预后之间的关系。方法 免疫组织化学S—P法测定。结果 P16蛋白阳性表达率为51.7％(31/60),其中,阳性(++)及强阳性(+++)者为25％(15/60),其表达与肿瘤分化程度,浸润范围,淋巴结转移,手术预后在统计学上有差异(P<0.01),而与组织类型,病人性别,年龄,肿瘤部位在统计学上无差异(P>0.05),结论 P16蛋白表达与食管、贲门癌的生物学行为及预后可能有关。
Objective To explore the relationship between tumor suppressor gene P16 expression in esophageal and cardiac cancer tissues and some pathological features and clinical prognosis of tumors. Methods Immunohistochemical S-P assay. Results The positive expression rate of P16 protein was 51.7% (31/60), of which positive (++) and strong positive (+++) were 25% (15/60), its expression was related to the degree of tumor differentiation and infiltration range. The prognosis of lymph node metastasis was statistically different (P<0.01), but there was no statistical difference (P>0.05) between tissue type, patient gender, age, and tumor site. Conclusion P16 protein expression and esophageal and cardiac cancer The biological behavior and prognosis may be related.